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Chemical Structure : AK306
Catalog No.: PC-35161Not For Human Use, Lab Use Only.
AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.
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AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.
AK306 demonstrates broad spectrum activity against of cancer cell lines with total growth inhibition values ranging from ~25 nM to 25 uM.
AK306 disrupts Aurora A localization, leading to the formation of multiple foci, induces a p53-dependent cell death, and centrosome disruption.
| M.Wt | 379.281 | |
| Formula | C19H20Cl2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bond MJ, et al. Mol Cancer Res. 2018 May 16. pii: molcanres.0178.2018.
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