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Chemical Structure : ARN-75039
Catalog No.: PC-72615Not For Human Use, Lab Use Only.
ARN-75039 (ARN75039) is a potent, small molecule fusion inhibitor of arenavirus, inhibits pseudotyped entry of pGTOV and pCHAPV with EC50 of 0.13 and 4.3 nM, respectively.
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ARN-75039 (ARN75039) is a potent, small molecule fusion inhibitor of arenavirus, inhibits pseudotyped entry of pGTOV and pCHAPV with EC50 of 0.13 and 4.3 nM, respectively.
ARN-75039 demonstrated sub-nanomolar EC50 activity against pTCRV that further translated to native wild-and NWAs, including LASV, JUNV and MACV, in pseudotyped virus assays and against native replicative LASV and JUNV.
ARN-75039 also potently inhibits mutant T434I pTCRV variant with EC50 of 29 nM.
ARN-75039 dramatically improved survival outcome and potently inhibited TCRV replication in serum and various tissues at doses of 10 and 35 mg/kg, provided highly significant post-exposure protection in mice against TCRV infection.
| M.Wt | 414.549 | |
| Formula | C27H30N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Brian B Gowen, et al. Antiviral Res. 2021 Sep;193:105125.
2. Michael B Plewe, et al. Bioorg Med Chem Lett. 2021 Jun 1;41:127983.
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