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Chemical Structure : AZD-4818
CAS No.: 1003566-93-5
Catalog No.: PC-62762Not For Human Use, Lab Use Only.
AZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $758 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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AZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner.
AZD-4818 significantly reduces neutrophil influx and TNF-α levels on bronchoalveolar lavage (BAL) following intratracheal administration in vivo.
| M.Wt | 567.46 | |
| Formula | C27H32Cl2N2O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[2-Chloro-5-[(2S)-3-(5-chlorospiro[benzofuran-2(3H),4'-piperidin]-1'-yl)-2-hydroxypropoxy]-4-[(methylamino)carbonyl]phenoxy]-2-methylpropanoic acid |
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1. Kerstjens HA, et al. Respir Med. 2010 Sep;104(9):1297-303.
2. Norman P. Expert Opin Ther Pat. 2009 Nov;19(11):1629-33.
3. Gilchrist A, et al. Br J Pharmacol. 2014 Nov;171(22):5127-38.
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