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Chemical Structure : Adaphostin
CAS No.: 241127-58-2
Catalog No.: PC-38592Not For Human Use, Lab Use Only.
Adaphostin (AG 957 Adamantyl Ester, NSC 680410) is a p210 Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 uM, induces apoptosis in T-lymphoblastic human leukemia cell lines with IC50 of 16.8-216.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $138 | In stock | |
| 100 mg | $298 | In stock | |
| 200 mg | $398 | In stock | |
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Adaphostin (AG 957 Adamantyl Ester, NSC 680410) is a p210 Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 uM, induces apoptosis in T-lymphoblastic human leukemia cell lines with IC50 of 16.8-216.3 nM.
Adaphostin decreased p210(bcr/abl) polypeptide levels in K562 cells, followed by caspase activation and accumulation of apoptotic cells.
Adaphostin down-regulated p210bcr/abl in K562 cells and inhibited granulocyte colony formation in CML specimens at lower concentrations without enhanced toxicity in normal progenitors.
| M.Wt | 393.5 | |
| Formula | C24H27NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Adamantyl 4-((2,5-dihydroxybenzyl)amino)benzoate |
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1. Svingen PA, et al. Clin Cancer Res. 2000 Jan;6(1):237-49.
2. Mow BM, et al. Blood. 2002 Jan 15;99(2):664-71.
3. Avramis IA, et al. Cancer Chemother Pharmacol. 2002 Dec;50(6):479-89.
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