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Chemical Structure : BAY-985
CAS No.: 2409479-29-2
Catalog No.: PC-73128Not For Human Use, Lab Use Only.
BAY-985 (BAY985) is a potent and highly selective TBK1/IKKε inhibitor with IC50 of 2 nM (low ATP assay).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 50 mg | $878 | In stock | |
| 100 mg | $1480 | In stock | |
| 1 g | Get quote |
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BAY-985 (BAY985) is a potent and highly selective TBK1/IKKε inhibitor with IC50 of 2 nM (low ATP assay).
BAY-985 displays high potency in the mechanistic pIRF3 assay (IC50=74 nM), and an antiproliferative effect on SK-MEL-2 cells (IC50=900 nM).
BAY-985 displayed good selectivity toward FLT3 (60×), RSK4 (138×), DRAK1 (155×), and ULK1 (-4000×), as well as high selectivity against in the DiscoverX KINOMEscan with exception of YSK4.
BAY-985 shows only weak antitumor activity in the SK-MEL-2 human melanoma xenograft model.
| M.Wt | 553.594 | |
| Formula | C27H30F3N9O | |
| Appearance | Solid | |
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1. Lefranc J, et al. J Med Chem. 2020 Jan 23;63(2):601-612.
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