Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BC-LI-0186
CAS No.: 695207-56-8
Catalog No.: PC-38333Not For Human Use, Lab Use Only.
BC-LI-0186 is a potent, specific inhibitor of Leucyl-tRNA synthetase (LRS), inhibits the leucine-dependent mTORC1 pathway.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BC-LI-0186 is a potent, specific inhibitor of Leucyl-tRNA synthetase (LRS, LeuRS), inhibits the leucine-dependent mTORC1 pathway.
BC-LI-0186 binds to the RagD interacting site of LRS with KD of 42.1 nM, thereby inhibiting lysosomal localization of LRS and mTORC1 activity.
BC-LI-0186 specifically inhibiting the GTPase activating function of LRS, while not affecting the catalytic activity.
BC-LI-0186binds to the RagD interacting site of LRS, thereby inhibiting lysosomal localization of LRS and mTORC1 activity.
BC-LI-0186 inhibited cancer cell growth human colon cancer SW620 cells with GI50 of 11 nM, inhibited mTORC1 activity, accompanied by PARP or procaspase-3 cleavage.
BC-LI-0186 inhibited the mTORC1 pathway via LRS even in the presence of the known cancer-associated MTOR mutations, overcome acquired rapamycin resistance both in vitro and in vivo.
| M.Wt | 429.535 | |
| Formula | C22H27N3O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide |
|
1. Choi H, et al. Biochem Biophys Res Commun. 2017 Nov 18;493(2):1129-1135.
2. Kim JH, et al. Nat Commun. 2017 Sep 29;8(1):732.
3. Son K, et al. J Clin Invest. 2019 Apr 15;129(5):2088-2093.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
