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Chemical Structure : BGB-283
CAS No.: 1446090-79-4
Catalog No.: PC-45573Not For Human Use, Lab Use Only.
BGB-283 (Lifirafenib, BGB283) is a potent pan RAF inhibitor of BRAF V600E, wt BRAF, CRAFY340/341D and wt ARAF (IC50=5-40 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $468 | In stock | |
| 100 mg | Get quote |
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BGB-283 (Lifirafenib, BGB283) is a potent pan RAF inhibitor of BRAF V600E, wt BRAF, CRAFY340/341D and wt ARAF (IC50=5-40 nM).
BGB-283 (Lifirafenib) inhibits recombinant BRAFV600E with IC50 of 23 nM; also inhibits EGFR and EGFR T790M/L858R with IC50 of 29 nM and 495 nM respectively.
BGB-283 (Lifirafenib) potently inhibits BRAF(V600E)-activated ERK phosphorylation and cell proliferation in vitro.
BGB-283 (Lifirafenib) shows tumor growth inhibition in both cell line-derived and primary human colorectal tumor xenografts bearing BRAF(V600E) mutation.
| M.Wt | 478.43 | |
| Formula | C25H17F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 125 mg/mL |
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| Chemical Name/SMILES |
5-[[(1R,1aS,6bR)-1a,6b-Dihydro-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1H-cyclopropa[b]benzofuran-5-yl]oxy]-3,4-dihydro-1,8-naphthyridin-2(1H)-one |
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1. Tang Z, et al. Mol Cancer Ther. 2015 Oct;14(10):2187-97.
2. Cancer Discov. 2016 Jul;6(7):OF1.
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