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Chemical Structure : BMS-641988
Catalog No.: PC-61086Not For Human Use, Lab Use Only.
BMS-641988 is a potent, selective, nonsteroidal androgen receptor antagonist with Ki of 1.7 nM, MDA-MB-453 cell IC50 of 16 nM.
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BMS-641988 is a potent, selective, nonsteroidal androgen receptor antagonist with Ki of 1.7 nM, MDA-MB-453 cell IC50 of 16 nM; displays high selectivity over the glucocorticoid and progesterone receptors; displayed 3-7-fold increased antagonist activity of AR transactivation compared with bicalutamide; strongly inhibits androgen-dependent growth of the ventral prostate and seminal vesicles in rats, and is efficacious in CWR-22-BMSLD1 tumors initially refractory to treatment with bicalutamide.
Prostate Cancer
Phase 1 Clinical
| M.Wt | 471.45 | |
| Formula | C20H20F3N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Balog A, et al. ACS Med Chem Lett. 2015 Jun 19;6(8):908-12.
2. Attar RM, et al. Cancer Res. 2009 Aug 15;69(16):6522-30.
3. Rathkopf D, et al. Clin Cancer Res. 2011 Feb 15;17(4):880-7.
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