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Chemical Structure : BMX-IN-1
CAS No.: 1431525-23-3
Catalog No.: PC-46005Not For Human Use, Lab Use Only.
BMX-IN-1 (CAS 1431525-23-3) is a potent, selective, irreversible inhibitor of BMX kinase with IC50 of 8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $316.8 | In stock | |
| 50 mg | $853.6 | In stock | |
| 100 mg | $1120 | In stock |
Bulk size, bulk discount!
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BMX-IN-1 (CAS 1431525-23-3) is a potent, selective, irreversible inhibitor of BMX kinase with IC50 of 8 nM; also inhibits BTK with IC50 of 10.4 nM and displays 47-656-fold less potent for Blk, JAK3, EGFR, Itk, or Tec; inhibits the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with GI50 of 25 nM, exhibits antiproliferative activity in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines with GI50 of 2-5 uM.
Prostate cancer
Preclinical
| M.Wt | 524.5903 | |
| Formula | C29H24N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Propenamide, N-[2-methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]- |
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1. Liu F, et al. ACS Chem Biol. 2013 Jul 19;8(7):1423-8.
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