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Chemical Structure : BYK191023
Catalog No.: PC-35418Not For Human Use, Lab Use Only.
BYK191023 (BYK-191023) is a potent, highly selective inhibitor of inducible nitric-oxide synthase (iNOS) with IC50 of 86 nM, >20-fold selectivity over nNOS and eNOS (IC50=17 and 162 uM).
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BYK191023 (BYK-191023) is a potent, highly selective inhibitor of inducible nitric-oxide synthase (iNOS) with IC50 of 86 nM, >20-fold selectivity over nNOS and eNOS (IC50=17 and 162 uM).
BYK191023 exhibits an affinity for iNOS, nNOS, and eNOS of 450 nM, 30 uM, and >500 uM, respectively.
BYK191023 inhibits cellular nitrate/nitrite synthesis in RAW, rat mesangium, and human embryonic kidney 293 cells with IC50 values 40- to 100-fold higher than at the isolated enzyme.
BYK191023 dose-dependently suppresses the LPS-induced increase in plasma nitrate/nitrite (NO(x)) levels with ED50 of 14.9 micromol/kg/h, partially restores normal blood pressure responses to norepinephrine and sodium nitroprusside in model of LPS-induced vascular hyporesponsiveness.
| M.Wt | 254.293 | |
| Formula | C14H14N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Strub A, et al. Mol Pharmacol. 2006 Jan;69(1):328-37.
2. Lehner MD, et al. J Pharmacol Exp Ther. 2006 Apr;317(1):181-7.
3. Tiso M, et al. Mol Pharmacol. 2008 Apr;73(4):1244-53.
4. Higashi Y, et al. Br J Pharmacol. 2018 Jul 14. doi: 10.1111/bph.14445.
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