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Chemical Structure : Bentamapimod
CAS No.: 848344-36-5
Catalog No.: PC-73183Not For Human Use, Lab Use Only.
Bentamapimod (AS602801) is a potent, selective, ATP-competitive JNK inhibitor with IC50 of 80/90/230 nM for JNK1/2/3, repectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | $398 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Bentamapimod (AS602801) is a potent, selective, ATP-competitive JNK inhibitor with IC50 of 80/90/230 nM for JNK1/2/3, repectively.
Bentamapimod (AS602801) induces cell death and accordingly decreased the number of viable cells in all three cell lines in a dose-dependent manner.
Bentamapimod (AS602801) exhibits cytotoxicity against both serum-cultured non-stem cancer cells and cancer stem cells derived from human pancreatic cancer, non-small cell lung cancer, ovarian cancer and glioblastoma.
Bentamapimod (AS602801) also inhibits the self-renewal and tumor-initiating capacity of cancer stem cells (CSCs).
Bentamapimod (AS602801) induces regression of endometriotic lesions in animal models.
| M.Wt | 457.55 | |
| Formula | C25H23N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile |
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1. Okada M, et al. Oncotarget. 2016 May 10;7(19):27021-32.
2. Kuramoto K, et al. Anticancer Res. 2018 Sep;38(9):5093-5099.
3. Yamamoto M, et al. Anticancer Res. 2019 Feb;39(2):609-617.
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