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Chemical Structure : CIL-56
CAS No.: 300802-28-2
Catalog No.: PC-60375Not For Human Use, Lab Use Only.
YAP1 inhibitor CA3 (CA3, CIL56) is a small molecule that has remarkable inhibitory activity on YAP1/Tead transcriptional activity
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $238 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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YAP1 inhibitor CA3 (CA3, CIL56) is a small molecule that has remarkable inhibitory activity on YAP1/Tead transcriptional activity
YAP1 inhibitor CA3 (CIL56) also demonstrates strong inhibitory effects on esophageal adenocarcinoma cell growth especially on YAP1 high-expressing esophageal adenocarcinoma cells both in vitro and in vivo.
YAP1 inhibitor CA3 (CIL56) can effectively suppress radiation-resistant cancer stem cell (CSC) properties and aggressive phenotype by inhibiting proliferation, inducing apoptosis, reducing tumor sphere formation; synergistically inhibits cancer cell growth combined with 5-FU.
YAP1 inhibitor CA3 (CIL56) triggers nonapoptotic cell death, a potent and selective probe of ferroptosis.
YAP1 inhibitor CA3 (CIL56) stimulates the activity of ACC1, inhibits the normal breakdown of fatty acids by mitochondrial β-oxidation.
| M.Wt | 489.6 | |
| Formula | C23H27N3O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,7-bis(piperidin-1-ylsulfonyl)-9H-fluoren-9-one oxime |
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1. Dixon SJ, et al. ACS Chem Biol. 2015 Jul 17;10(7):1604-9.
2. Song S, et al. Mol Cancer Ther. 2018 Feb;17(2):443-454.
3. Shimada K, et al. Nat Chem Biol. 2016 Jul;12(7):497-503.
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