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Chemical Structure : CK-37
Catalog No.: PC-61516Not For Human Use, Lab Use Only.
A potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site.
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A potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site; significantly increases LC3II expression in MCF-7 and MCF-7/TAM cells, increases the size and number of autophagosome, causes MCF-7 and MCF-7/TAM cells to a slight increase in p62; suppresses MAPK and PI3K/AKT signaling, disrupts actin cytoskeletal organization, and reduces plasma membrane ruffling; significantly decreases tumor growth in a lung tumor xenograft mouse model, suppresses tumor phosphocholine, and diminishes activating phosphorylations of ERK and AKT in vivo.
| M.Wt | 366.483 | |
| Formula | C20H22N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Clem BF, et al. Oncogene. 2011 Jul 28;30(30):3370-80.
2. Kim HS, et al. PLoS One. 2015 Oct 23;10(10):e0141110.
3. Wong MT, et al. J Virol. 2016 Sep 29;90(20):9075-95.
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