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Chemical Structure : Cyclopamine
CAS No.: 4449-51-8
Catalog No.: PC-45147Not For Human Use, Lab Use Only.
A natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $52 | In stock | |
| 50 mg | $120.8 | In stock | |
| 100 mg | $188.8 | In stock |
Bulk size, bulk discount!
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A natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM; inhibits hedgehog-dependent expression of Pax7 with IC50 of 24 nM, blocks the response of neural plate explants to recombinant Shh-N; A useful tool in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
| M.Wt | 411.6199 | |
| Formula | C27H41NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 0.32 mg/mL (Need ultrasonic) |
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| Chemical Name/SMILES |
Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)- |
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1. Peukert S, et al. Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31.
2. Cooper MK, et al. Science. 1998 Jun 5;280(5369):1603-7.
3. Incardona JP, et al. Development. 1998 Sep;125(18):3553-62.
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