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Chemical Structure : DS44960156
Catalog No.: PC-73015Not For Human Use, Lab Use Only.
DS44960156 (DS 44960156) is a isozyme-selective MTHFD2 inhibitor with IC50 of 1.6 uM, without inhibitory effect against MTHFD1 (IC50>30 uM).
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DS44960156 (DS 44960156) is a isozyme-selective MTHFD2 inhibitor with IC50 of 1.6 uM, without inhibitory effect against MTHFD1 (IC50>30 uM).
Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a human mitochondrial enzyme that is known to play a key role in purine and thymidine syntheses by generating one-carbon (1C) units from serine.
MTHFD2 mRNA and protein are significantly increased in various types of tumors and that patients with high levels of MTHFD2 show a poor prognosis.
| M.Wt | 349.3 | |
| Formula | C20H15NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kawai J, et al. ACS Med Chem Lett. 2019 May 24;10(6):893-898.
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