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Chemical Structure : EN219
Catalog No.: PC-73229Not For Human Use, Lab Use Only.
EN219 is a fully synthetic covalent ligand that targets RNF114, recruites the E3 ubiquitin ligase RNF114 for targeted protein degradation.
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EN219 is a fully synthetic covalent ligand that targets RNF114, recruites the E3 ubiquitin ligase RNF114 for targeted protein degradation.
EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM.
EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination.
EN219 can be used as an RNF114 recruiter in degrader applications (RNF114-based PROTACs).
| M.Wt | 456.56 | |
| Formula | C17H13Br2ClN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Luo M, et al. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15.
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