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Chemical Structure : Elubrixin
Catalog No.: PC-62989Not For Human Use, Lab Use Only.
Elubrixin (SB-656933, GSK-656933) is a potent, selective, competitive and reversible CXCR2 antagonist.
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Elubrixin (SB-656933;GSK-656933) is a potent, selective, competitive and reversible CXCR2 antagonist; inhibits CXCL1-induced CD11b up-regulation on PMNs in an in vitro whole blood assay and to be active in in vivo rodent inhalation challenge models of airway inflammation that used endotoxin and ozone to induce airway neutrophilia.
Fibrosis
Phase 2 Discontinued
| M.Wt | 463.305 | |
| Formula | C17H17Cl2FN4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lazaar AL, et al. Br J Clin Pharmacol. 2011 Aug;72(2):282-93.
2. Nicholson GC, et al. Pulm Pharmacol Ther. 2007;20(1):52-9.
3. Kaur M, et al. J Pharmacol Exp Ther. 2013 Oct;347(1):173-80.
4. Busch-Petersen J, et al. Curr Top Med Chem. 2006;6(13):1345-52.
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