Chemical Structure : FLLL-32
CAS No.: 1226895-15-3
Catalog No.: PC-61668Not For Human Use, Lab Use Only.
FLLL-32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM).
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5 mg | $198 | In stock | |
25 mg | $458 | In stock | |
100 mg | $1280 | In stock | |
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FLLL-32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM); induces apoptosis in pancreatic and breast cancer cell lines; also inhibit colony formation in soft agar and cell invasion and exhibits synergy with Doxorubicin against breast cancer cells; decreases STAT3 DNA binding activity and expression, and induces apoptosis in several cancer cell lines.
M.Wt | 464.6 | |
Formula | C28H32O6 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)]-2-propen-1-one |
1. Lin L, et al. Cancer Res. 2010 Mar 15;70(6):2445-54.
2. Bill MA, et al. Mol Cancer. 2010 Jun 25;9:165.
3. Fossey SL, et al. BMC Cancer. 2011 Mar 28;11:112.
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