Chemical Structure : Filanesib
CAS No.: 885060-09-3
Catalog No.: PC-73188Not For Human Use, Lab Use Only.
Filanesib (ARRY-520) is a potent, selective and noncompetitive kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
Packing | Price | Stock | Quantity |
---|---|---|---|
10 mg | $128 | In stock | |
25 mg | $198 | In stock | |
50 mg | $328 | In stock | |
100 mg | $528 | In stock | |
1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Filanesib (ARRY-520) is a potent, selective and noncompetitive kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
Filanesib (ARRY-520) induces mitotic arrest in multiple cell lines.
Filanesib (ARRY-520) exhibits anti-proliferative against a broad range of human and rodent tumor cell lines, including a variety of leukemias and solid tumors, with EC50 of 0.4-14.4 nM.
Filanesib (ARRY-520) causes accumulation of cells in the G2/M phase of the cell cycle in a dose-dependent manner in HeLa cells, induces caspase-2 activation.
Filanesib (ARRY-520) demonstrates anti-tumor activitiy in vivo.
M.Wt | 420.48 | |
Formula | C20H22F2N4O2S | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
|
1. Christine Lemieux, et al. AACR Annual Meeting. 2007.
2. Woessner R, et al. Anticancer Res. 2009 Nov;29(11):4373-80.
3. Carter BZ, et al. Leukemia. 2009 Oct;23(10):1755-62.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright