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GANT 58

Chemical Structure : GANT 58

CAS No.: 64048-12-0

GANT 58 (NSC 75503;GANT58;GANT-58;NSC-75503)

Catalog No.: PC-43461Not For Human Use, Lab Use Only.

GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM.
GANT 58 efficiently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth in an in vivo xenograft model of human prostate cancer cells harboring downstream activation of the Hh pathway.

Physicochemical Properties

M.Wt
Formula C24H16N4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Pyridine, 4,4',4'',4'''-(2,3,4,5-thiophenetetrayl)tetrakis-

References

1. Lauth M, et al. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60.

2. Hassounah NB, et al. Clin Cancer Res. 2012 May 1;18(9):2429-35.

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