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Chemical Structure : GAP-134 hydrochloride
CAS No.: 943133-81-1
Catalog No.: PC-42736Not For Human Use, Lab Use Only.
A potent, orally active gap-junction modifier.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $295.2 | In stock | |
| 50 mg | $796.8 | In stock |
Bulk size, bulk discount!
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A potent, orally active gap-junction modifier; prevents significantly conduction velocity slowing at 10 nM compared with vehicle; has highly desirable in vitro and in vivo safety profile including (1) lack of direct effects on membrane ion currents, hERG inhibition, and CYP450 liabilities, (2) negative AMES result, (3) a benign NovaScreen profile, and (4) no effects on systemic hemodynamics.
Heart Arrhythmia
Phase 2 Discontinued
| M.Wt | 327.7634 | |
| Formula | C14H18ClN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-Proline, glycyl-4-(benzoylamino)-, hydrochloride (1:1), (4R)- |
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1. Butera JA, et al. J Med Chem. 2009 Feb 26;52(4):908-11.
2. Rossman EI, et al. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33.
3. Hennan JK, et al. J Cardiovasc Pharmacol Ther. 2009 Sep;14(3):207-14.
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