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GB1107

Chemical Structure : GB1107

CAS No.: 1978336-61-6

GB1107 (GB-1107;GB 1107)

Catalog No.: PC-36033Not For Human Use, Lab Use Only.

GB1107 (GB-1107, GB 1107) is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with Kd of 37 nM (human Galectin-3).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GB1107 (GB-1107, GB 1107) is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with Kd of 37 nM (human Galectin-3).
GB1107 displays >100-fold lower affinity for most of the tested human galectins, and 20 and 4-fold lower affinity for galectin-2 and the C-terminal CRD of galectin-4, respectively.
GB1107 prevents human lung adenocarcinoma growth in vivo, increases tumor M1 macrophage polarization and CD8+ T cell infiltration.
GB1107 also can potentiate the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules.

Physicochemical Properties

M.Wt 522.32
Formula C20H16Cl2F3N3O4S
CAS No. 1978336-61-6
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

100 mM in DMSO (52.2 mg/mL)

Chemical Name

3,4-dichlorophenyl 3-deoxy-3-[4(3,4,5-trifluorophenyl)-1H-1,2,3- triazol-1-yl]-1-thio-α-D-galactopyranoside

References

1. Vuong L, et al. Cancer Res. 2019 Jan, doi: 10.1158/0008-5472.CAN-18-2244.

2. Zetterberg FR, et al. ChemMedChem. 2018 Jan 22;13(2):133-137.

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