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Chemical Structure : GNE-7915
CAS No.: 1351761-44-8
Catalog No.: PC-45424Not For Human Use, Lab Use Only.
GNE-7915 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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GNE-7915 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM.
GNE-7915 shows 1/187 kinases with 50% inhibition at 0.1 uM.
GNE-7915 possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species.
| M.Wt | 443.3954 | |
| Formula | C19H21F4N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 14.33 mg/mL |
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| Chemical Name/SMILES |
Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl- |
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1. Estrada AA, et al. J Med Chem. 2012 Nov 26;55(22):9416-33.
2. Fuji RN, et al. Sci Transl Med. 2015 Feb 4;7(273):273ra15.
3. Kavanagh ME, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3690-6.
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