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Chemical Structure : GS-621763
CAS No.: 2647442-13-3
Catalog No.: PC-38459Not For Human Use, Lab Use Only.
GS-621763 is an oral prodrug of remdesivir parent nucleoside GS-441524, inhibits SARS-CoV-2, including variants of concern in cell culture (EC50=0.11 to 0.73 uM) and human airway epithelium organoids.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 25 mg | $528 | In stock | |
| 100 mg | $1380 | In stock | |
| 200 mg | $2080 | In stock | |
| 1 g | Get quote |
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GS-621763 is an oral prodrug of remdesivir parent nucleoside GS-441524, inhibits SARS-CoV-2, including variants of concern in cell culture (EC50=0.11 to 0.73 uM) and human airway epithelium organoids.
Oral GS-621763 is efficiently converted to plasma metabolite GS-441524, and in lungs to the triphosphate metabolite identical to that generated by remdesivir, demonstrating a consistent mechanism of activity.
Twice-daily oral administration of 10 mg/kg GS-621763 reduces SARS-CoV-2 burden to near-undetectable levels in ferrets. GS-621763 blocks virus replication and prevents transmission to untreated contact animals SARS-CoV-2 strain P.1 gamma γ.
GS-621763 administration reduced viral load and lung pathology, improved pulmonary function in COVID-19 mouse model.
| M.Wt | 501.540 | |
| Formula | C24H31N5O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate) |
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1. Cox RM, et al. Nat Commun. 2021 Nov 5;12(1):6415.
2. Schäfer A, et al. Sci Transl Med. 2022 Mar 22:eabm3410.
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