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GSK-2324

Chemical Structure : GSK-2324

CAS No.: 1020567-30-9

GSK-2324 (GSK2324;GSK 2324)

Catalog No.: PC-60080Not For Human Use, Lab Use Only.

GSK-2324 (GSK2324) is a potent, selective, full FXR agonist with EC50 of 120 nM in FRET assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GSK-2324 (GSK2324) is a potent, selective, full FXR agonist with EC50 of 120 nM in FRET assay.
GSK-2324 lowers body weight gain and serum glucose in a DIO mouse model of diabetes.

Physicochemical Properties

M.Wt 533.405
Formula C29H22Cl2N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)quinoline-2-carboxylic acid

References

1. Bass JY, et al. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1206-13.

2. de Aguiar Vallim TQ, et al. Circ Res. 2013 Jun 7;112(12):1602-12.

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