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Chemical Structure : GSK8612
CAS No.: 2361659-62-1
Catalog No.: PC-38171Not For Human Use, Lab Use Only.
GSK8612 (GSK-8612) is a highly selective, potent TBK1 inhibitor, inhibits recombinant TBK1 with pIC50 of 6.8 in biochemical functional assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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GSK8612 (GSK-8612) is a highly selective, potent TBK1 inhibitor, inhibits recombinant TBK1 with pIC50 of 6.8 in biochemical functional assays.
GSK8612 demonstrated inhibition of IRF3 phosphorylation in Ramos cells, IFNα secretion from human PBMCs, and IFNβ secretion from THP-1 cells with low micromolar potency.
| M.Wt | 520.329 | |
| Formula | C17H17BrF3N7O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-((5-bromo-2-((3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-ylamino)methyl)benzenesulfonamide |
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1. Thomson DW, et al. ACS Med Chem Lett. 2019 Mar 11;10(5):780-785.
2. Chen S, et al. Am J Transl Res. 2021 Dec 15;13(12):13640-13653.
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