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Chemical Structure : Gemopatrilat
Catalog No.: PC-60710Not For Human Use, Lab Use Only.
A potent, orally available, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 12 and 63 nM, respectively.
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A potent, orally available, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 12 and 63 nM, respectively; causes prolonged inhibition of circulating and renal ACE and renal NEP after a single oral dose in atherogenic diet rabbits.
Heart Failure
Phase 2 Discontinued
| M.Wt | 378.49 | |
| Formula | C19H26N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hubner RA, et al. J Hypertens. 2001 May;19(5):941-6.
2. Singh J, et al. Org Lett. 2003 Aug 21;5(17):3155-8.
3. Robl JA, et al. J Med Chem. 1999 Jan 28;42(2):305-11.
4. Laverman GD, et al. Kidney Int. 2003 Jan;63(1):64-71.
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