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HMCEF

Chemical Structure : HMCEF

CAS No.: 2002363-68-8

HMCEF

Catalog No.: PC-60181Not For Human Use, Lab Use Only.

A novel P-selectin inhibitor that directly binds to P-selectin.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel P-selectin inhibitor that directly binds to P-selectin; intercalates into calf thymus DNA, cuts off DNA pBR22 and inhibits the proliferation of cancer cells; dose dependently inhibits inflammatory response of mice and inhibits thrombosis and inflammation, decreases serum TNFα and IL-8.

Physicochemical Properties

M.Wt 389.455
Formula C23H23N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2-(3-(hydroxymethyl)-9H-pyrido[3,4-b]indol-1-yl)ethyl)-L-phenylalanine

References

1. Wu J, et al. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4631-6.

2. Wu J, et al. Drug Des Devel Ther. 2017 Jan 17;11:225-239.

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