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Chemical Structure : IC 86621
Catalog No.: PC-62996Not For Human Use, Lab Use Only.
IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM).
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IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM); directly inhibits the repair of DNA DSBs and consequently enhances the cytotoxicity of physical and chemical agents that induce DSBs but not other DNA lesions.
| M.Wt | 221.256 | |
| Formula | C12H15NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kashishian A, et al. Mol Cancer Ther. 2003 Dec;2(12):1257-64.
2. Allen C, et al. Mol Cancer Res. 2003 Oct;1(12):913-20.
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