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ITE

Chemical Structure : ITE

CAS No.: 448906-42-1

ITE

Catalog No.: PC-45600Not For Human Use, Lab Use Only.

A endogenous ligand, potent aryl hydrocarbon receptor (AhR) agonist in vitro.

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Biological Activity

A endogenous ligand, potent aryl hydrocarbon receptor (AhR) agonist in vitro; activates the murine AhR in vivo, but does not induce toxicity; induces the differentiation of stem-like cancer cells and reduces their tumorigenic potential in both subcutaneous and orthotopic xenograft tumour models.

Physicochemical Properties

M.Wt 286.3058
Formula C14H10N2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 41 mg/mL

Chemical Name/SMILES

4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester

References

1. Henry EC, et al. Toxicol Sci. 2010 Mar;114(1):90-100.

2. Wang K, et al. Cancer Lett. 2013 Oct 28;340(1):63-71.

3. Cheng J, et al. Nat Commun. 2015 Jun 10;6:7209.

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