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Chemical Structure : JK184
CAS No.: 315703-52-7
Catalog No.: PC-43482Not For Human Use, Lab Use Only.
JK184 is an antagonist of the hedgehog (Hh) signaling pathway with IC50 of 30 nM, inhibits glioma (Gli)-dependent transcriptional activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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JK184 is an antagonist of the hedgehog (Hh) signaling pathway with IC50 of 30 nM, inhibits glioma (Gli)-dependent transcriptional activity.
JK184 inhibits GLI1 mRNA expression and decreases the number of colonies formed in TN-IBC (SUM149) and TNBC (MDA-MB-231 and SUM159) cell lines.
JK184 significantly down-regulates GLI1 targets that regulate cell cycle (cyclin D and E) and apoptosis (Bcl2).
JK184 is a potent inhibitor of microtubule assembly and that microtubule-depolymerizing agents can either negatively or positively regulate the Gli family of transcription factors, dependending on the mechanism by which the pathway is activated.
| M.Wt | ||
| Formula | C19H18N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Thiazolamine, N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)- |
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1. Cupido T, et al. Angew Chem Int Ed Engl. 2009;48(13):2321-4.
2. Colavito SA, et al. Breast Cancer Res. 2014 Sep 25;16(5):444.
3. Oladapo HO, et al. Cancer Lett. 2017 Dec 28;411:136-149.
4. Lee J, et al. Chembiochem. 2007 Nov 5;8(16):1916-9.
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