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Chemical Structure : LY2780301
Catalog No.: PC-61416Not For Human Use, Lab Use Only.
LY2780301 is a potent, highly selective, ATP-competitive dual inhibitor of p70S6K and Akt under development for the treatment of solid tumours and non-Hodgkin's lymphoma.
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LY2780301 is a potent, highly selective, ATP-competitive dual inhibitor of p70S6K and Akt under development for the treatment of solid tumours and non-Hodgkin's lymphoma.
LY2780301 drastically decreases proliferation of hMECs with ErbB2-induced p70S6K activation via Cyclin B1 inhibition and cell cycle blockade at G0-G1 phase.
LY2780301 exhibited antiproliferative activity in a broad range of cell lines using monolayer and colony formation assays, reduces proliferation of hMECs in vitro and ADH/MIN lesions in vivo.
| M.Wt | 517.533 | |
| Formula | C25H27F4N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Azaro A, et al. Invest New Drugs. 2015 Jun;33(3):710-9.
2. Wang X, et al. Cancer Prev Res (Phila). 2017 Sep 6. pii: canprevres.0106.2017.
3. Angevin E, et al. Eur J Cancer. 2017 Sep;83:194-202.
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