LY3023703 | mPGES-1 inhibitor | Probechem Biochemicals

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Chemical Structure : LY3023703

LY3023703 (LY 3023703)

Catalog No.: PC-38689Not For Human Use, Lab Use Only.

LY3023703 is a potent, highly selective microsomal prostaglandin E synthase 1 (mPGES1) inhibitor, dose-dependently inhibits PGE2 production in human whole blood ex vivo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LY3023703 is a potent, highly selective microsomal prostaglandin E synthase 1 (mPGES1) inhibitor, dose-dependently inhibits PGE2 production in human whole blood ex vivo.

Physicochemical Properties

M.Wt	495.454
Formula	C23H22F5N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(Difluoromethyl)-5-[[(2-methyl-1-oxopropyl)amino]methyl]-N-[4-methyl-5-[4-(trifluoromethyl)phenyl]-1H-imidazol-2-yl]-3-pyridinecarboxamide

References

1. Norman BH, et al. J Med Chem. 2018 Mar 8;61(5):2041-2051.

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LY3023703 (LY 3023703)

Biological Activity

Physicochemical Properties

References

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