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Chemical Structure : MIR17PTi
Catalog No.: PC-35397Not For Human Use, Lab Use Only.
MIR17PTi is a novel LNA gapmeR antisense oligonucleotide (LNA-ASO), first-in-class inhibitor of pri-mir-17-92.
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MIR17PTi is a novel LNA gapmeR antisense oligonucleotide (LNA-ASO), first-in-class inhibitor of pri-mir-17-92; impairs the proliferation of several cancer cell lines established from both solid and hematologic tumors by on-target antisense activity, and more effectively as compared to miR-17-92s inhibitors; triggers apoptosis via impairment of homeostatic MYC/miR-17-92 feed-forward loops (FFLs) in patient-derived MM cells, induces MYC-dependent synthetic lethality; exerts strong in vivo anti-tumor activity in NOD-SCID mice bearing clinically relevant models of MM.
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10 mM in DMSO |
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1. Morelli E, et al. Blood. 2018 Jul 11. pii: blood-2018-03-836601.
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