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Chemical Structure : ML327
Catalog No.: PC-62145Not For Human Use, Lab Use Only.
ML327 is a small molecule that restores E-cadherin expression through regulation of E-cadherin transcription, displays an In-Cell Western EC50 of 1.0 uM.
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ML327 is a small molecule that restores E-cadherin expression through regulation of E-cadherin transcription, displays an In-Cell Western EC50 of 1.0 uM; is inactive (>30 uM) against all know epigenetic targets (HDACs, MMPs, Sirtuins, etc.) that increase E-cadherin expression, and clean in a Ricerca ancillary pharmacology panel; possesses favorable physiochemical properties, an excellent dystrophia myotonica protein kinase (DMPK) profile.
| M.Wt | 366.377 | |
| Formula | C19H18N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. An H, et al. Oncotarget. 2015 Sep 8;6(26):22934-48.
2. Brogan JT, et al. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4260-4.
3. Rellinger EJ, et al. Oncotarget. 2017 Jul 20;8(53):91040-91051.
4. Rellinger EJ, et al. Biochem Biophys Res Commun. 2017 Sep 16;491(2):463-468.
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