Chemical Structure : MMV390048
CAS No.: 1314883-11-8
Catalog No.: PC-61691Not For Human Use, Lab Use Only.
MMV390048 is a novel potent Plasmodium PI4K inhibitor with IC50 of 28 nM against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MMV390048 is a novel potent Plasmodium PI4K inhibitor with IC50 of 28 nM against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain); blocks all life cycle stages of the malaria parasite, exhibits full chemoprotection, delays relapse in a Plasmodium cynomolgi monkey model.
Parasite Infection
Phase 2 Clinical
M.Wt | 393.3842 | |
Formula | C18H14F3N3O2S | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
5-(4-(methylsulfonyl)phenyl)-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine |
1. Paquet T, et al. Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright