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Chemical Structure : MYCMI-6
CAS No.: 681282-09-7
Catalog No.: PC-35303Not For Human Use, Lab Use Only.
MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction, blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with Kd of 1.6 uM in SPR assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $478 | In stock | |
| 25 mg | $758 | In stock | |
| 100 mg | Get quote |
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MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction, blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with Kd of 1.6 uM in SPR assay.
MYCMI-6 specifcally targets MYC:MAX interaction without interfering with other MYC activities.
MYCMI-6 selectively suppresses MYC-driven tumor cell growth with high efficacy, efficiently inhibits anchorage-independent growth of MYCN-amplifed neuroblastoma cells with GI50 values of <0.4, 5 and 0.75 μM, respectively.
MYCMI-6 reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects
| M.Wt | 373.42 | |
| Formula | C20H19N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-3-((9-amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine |
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1. Castell A, et al. Sci Rep. 2018 Jul 3;8(1):10064.
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