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Chemical Structure : NCB-0846
CAS No.: 1792999-26-8
Catalog No.: PC-42270Not For Human Use, Lab Use Only.
The first orally available, small-molecule TNIK inhibitor with IC50 of 21 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $156 | In stock | |
| 25 mg | $316 | In stock | |
| 50 mg | $544 | In stock | |
| 100 mg | $960 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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The first orally available, small-molecule TNIK inhibitor with IC50 of 21 nM; also weakly inhibits FLT3, JAK3, PDGFRα, TRKA, CDK2/CycA2, and HGK (IC80>0.1 uM); induces faster migration of TCF4 phosphorylated by TNIK at 0.1-0.3 uM, and completely inhibits at 3 uM; also reduces the expression of TNIK, AXIN2, cMYC, LRP6 and LRP5; abrogates colorectal cancer stemness, suppresses Wnt-driven intestinal tumorigenesis in Apc(min/+) mice.
Colon Cancer
Preclinical
| M.Wt | 375.4237 | |
| Formula | C21H21N5O2 | |
| CAS No. | 1792999-26-8 | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name |
Cyclohexanol, 4-[[2-(1H-benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-, cis- |
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1. Masuda M, et al. Nat Commun. 2016 Aug 26;7:12586.
2. Yamada T, et al. Cancer Sci. 2017 May;108(5):818-823.
3. Mahmoudi T, et al. EMBO J. 2009 Nov 4;28(21):3329-40.
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