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Chemical Structure : NSC-305787
CAS No.: 785718-37-8
Catalog No.: PC-45560Not For Human Use, Lab Use Only.
A small molecule inhibitor of Ezrin with Kd of 5.85 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
Bulk size, bulk discount!
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A small molecule inhibitor of Ezrin with Kd of 5.85 uM; inhibits ezrin phosphorylation, ezrin-actin interaction and ezrin-mediated motility of osteosarcoma (OS) cells in culture; inhibits lung metastasis of ezrin-sensitive cells in mice; also inhibits SHIP-1 and SHIP-2.
| M.Wt | 445.4245 | |
| Formula | C25H30Cl2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-Quinolinemethanol, 6,8-dichloro-α-2-piperidinyl-2-tricyclo[3.3.1.13,7]dec-1-yl- |
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1. Bulut G, et al. Oncogene. 2012 Jan 19;31(3):269-81.
2. Russo CM, et al. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5344-8.
3. Çelik H, et al. J Biol Chem. 2016 Jun 17;291(25):13257-70.
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