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Chemical Structure : NV-5138
CAS No.: 2095886-80-7
Catalog No.: PC-38176Not For Human Use, Lab Use Only.
NV-5138 (NV5138) is the first selective, orally bioavailable brain mTORC1 activator, binds to Sestrin2 (Kd=1.5 uM) and activates mTORC1 both in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 50 mg | $788 | In stock | |
| 100 mg | Get quote |
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NV-5138 (NV5138) is the first selective, orally bioavailable brain mTORC1 activator, binds to Sestrin2 (Kd=1.5 uM) and activates mTORC1 both in vitro and in vivo.
NV-5138 activates mTORC1 by modulating the interaction between Sestrin2 and GATOR2 in cells.
NV-5138 is a selective small molecule that binds to Sestrin1/2 and differentiates from the natural ligand leucine by the lack of metabolism via the BCAT pathway and utilization in protein synthesis.
NV-5138 transiently activates mTORC1 in the brain in vivo.
A single dose of NV-5138 produced rapid and long-lasting antidepressant effects, and rapidly reversed anhedonia caused by chronic stress exposure.
NV-5138 also rapidly increased synapse number and function in the mPFC, and reversed the synaptic deficits caused by chronic stress in vivo.
| M.Wt | 181.183 | |
| Formula | C7H13F2NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid |
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1. Sengupta S, et al. Sci Rep. 2019 Mar 11;9(1):4107.
2. Kato T, et al. J Clin Invest. 2019 Apr 16;129(6):2542-2554.
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