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Chemical Structure : Nutlin-3a
CAS No.: 675576-98-4
Catalog No.: PC-42100Not For Human Use, Lab Use Only.
Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | Get quote |
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Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay.
Nutlin-3a blocks the binding of Mdm2 to key signaling molecules such as p53 and p73α and can result in activation of cell death signaling pathways.
| M.Wt | 581.4896 | |
| Formula | C30H30Cl2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]- |
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1. Vassilev LT, et al. Science, 2004, 303(5659), 844-848.
2. Schneider LS, et al. Mol Oncol. 2016 Aug;10(7):1054-62.
3. Tonsing-Carter E, et al. Mol Cancer Ther. 2015 Dec;14(12):2850-63.
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