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Chemical Structure : PF-06447475
CAS No.: 1527473-33-1
Catalog No.: PC-43053Not For Human Use, Lab Use Only.
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 of 3 and 11nM for WT LRRK2 and G2019S mutant, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $145 | In stock | |
| 50 mg | $245 | In stock | |
| 100 mg | $425 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 of 3 and 11nM for WT LRRK2 and G2019S mutant, respectively.
PF-06447475 is also sufficiently potent in the LRRK2 whole cell assay with IC50 of 25 nM.
PF-06447475 protects nerve-like differentiated cells (NLCs) against rotenone induced noxious effect, prevents α-synuclein-induced neurodegeneration in rats.
| M.Wt | 305.3339 | |
| Formula | C17H15N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Benzonitrile, 3-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]- |
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1. Henderson JL, et al. J Med Chem. 2015 Jan 8;58(1):419-32.
2. Daher JP, et al. J Biol Chem. 2015 Aug 7;290(32):19433-44.
3. Mendivil-Perez M, et al. Neurochem Res. 2016 Oct;41(10):2675-2692.
4. Volpicelli-Daley LA, et al. J Neurosci. 2016 Jul 13;36(28):7415-27.
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