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Chemical Structure : PKCθ inhibitor 22
Catalog No.: PC-73053Not For Human Use, Lab Use Only.
PKCθ inhibitor 22 is a potent, selective, orally bioavailable inhibitor of Protein Kinase Cθ (PKCθ) with IC50 of 6 nM.
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PKCθ inhibitor 22 is a potent, selective, orally bioavailable inhibitor of Protein Kinase Cθ (PKCθ) with IC50 of 6 nM.
PKCθ inhibitor 22 inhibits IL-2 release from PBMCs following stimulation with anti-CD3/CD28 (IC50=0.19 uM).
PKCθ inhibitor 22 also inhibits the release of IL-17 from CD3/CD28 stimulated Th-17 cells with an IC50 of 1 uM.
PKCθ inhibitor 22 demonstrated a reduction of symptoms in a mouse model of multiple sclerosis.
| M.Wt | 348.329 | |
| Formula | C17H15F3N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Collier PN, et al. ACS Med Chem Lett. 2019 Jun 27;10(8):1134-1139.
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