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Chemical Structure : PQR-620
CAS No.: 1927857-56-4
Catalog No.: PC-42038Not For Human Use, Lab Use Only.
PQR-620 (PQR620) is a potent and selective, brain penetrant inhibitor of mTORC1/2, displays >1000-fold selectivity towards mTOR over PI3Kα in enzymatic binding assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PQR-620 (PQR620) is a potent and selective, brain penetrant inhibitor of mTORC1/2, displays >1000-fold selectivity towards mTOR over PI3Kα in enzymatic binding assays.
PQR620 demonstrates inhibition of protein kinase B (pSer473) and ribosomal protein S6 (pSer235/236) phosphorylation with IC50 of 0.2 uM and 0.1 uM, respectively.
PQR620 shows anti-tumor effects in vitro and in vivo.
| M.Wt | 445.4657 | |
| Formula | C21H25F2N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.4 mg/mL (Need warming) |
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| Chemical Name/SMILES |
5-(4,6-di((1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1,3,5-triazin-2-yl)-4-(difluoromethyl)pyridin-2-amine |
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1. Florent Beaufils, et al. Cancer Res, Abstract 1336 DOI: 10.1158/1538-7445.AM2016-1336 Published July 2016
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