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Chemical Structure : PRI-724
CAS No.: 1422253-38-0
Catalog No.: PC-70120Not For Human Use, Lab Use Only.
PRI-724 (Foscenvivint, OP-724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $478 | In stock | |
| 100 mg | Get quote |
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PRI-724 (Foscenvivint, OP-724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM.
PRI-724 (OP-724) binds specifically to the co-activator CBP, but not to p300.
PRI-724 (OP-724) selectively induces apoptosis in colon carcinoma cells but not in normal colon cells, and exhibits antitumor activity in the mouse xenograft models of colon cancer.
| M.Wt | 658.65 | |
| Formula | C33H35N6O7P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(((6S,9S,9aS)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-2H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl dihydrogen phosphate |
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1. Sasaki T, et al. Transl Respir Med. 2014 Sep 11;2:8.
2. Zhang X, et al. Am J Cancer Res. 2015 Jul 15;5(8):2344-60.
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