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Chemical Structure : PTC-209
CAS No.: 315704-66-6
Catalog No.: PC-36171Not For Human Use, Lab Use Only.
PTC-209 (PTC209) is a specific BMI-1 inhibitor with IC50 of 0.5 uM, irreversibly impairs colorectal cancer-initiating cell (CIC) growth.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PTC-209 (PTC209) is a specific BMI-1 inhibitor with IC50 of 0.5 uM, irreversibly impairs colorectal cancer-initiating cell (CIC) growth.
PTC-209 causes cell cycle arrest at the G1/S checkpoint in biliary tract cancer (BTC) cells, decreases BMI1 and increases p16 protein expression in canine OSA cell lines.
PTC-209 reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo, reducing their tumorigenic potential.
| M.Wt | 495.2 | |
| Formula | C17H13Br2N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine |
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1. Kreso A, et al. Nat Med. 2014 Jan;20(1):29-36.
2. Mourgues L, et al. Leukemia. 2015 Oct;29(10):1993-2002.
3. Nishida Y, et al. Cancer Sci. 2015 Dec;106(12):1705-13.
4. Mayr C, et al.Oncotarget. 2016 Jan 5;7(1):745-58.
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