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Chemical Structure : Peptide Fz7-21
Catalog No.: PC-63300Not For Human Use, Lab Use Only.
Peptide Fz7-21 is a potent, selective peptide inhibitor of Frizzled 7 receptor, inhibits exogenous WNT3A stimulated Wnt-β-catenin signaling in HEK293 cells with IC50 of 100 nM.
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Peptide Fz7-21 is a potent, selective peptide inhibitor of Frizzled 7 receptor, inhibits exogenous WNT3A stimulated Wnt-β-catenin signaling in HEK293 cells with IC50 of 100 nM; also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC50 of 50 nM; shows isoform-selective binding to the Fc-tagged FZD1, FZD2 and FZD7 CRDs with EC50 of 19-58 nM, whereas little to no binding to the FZD4, FZD5, FZD8, FZD9 or FZD10 CRDs; impaires Wnt signaling in cultured cells and stem cell function in intestinal organoids.
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Nile AH, et al. Nat Chem Biol. 2018 Apr 9. doi: 10.1038/s41589-018-0035-2.
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