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Chemical Structure : RUSKI-201
Catalog No.: PC-70165Not For Human Use, Lab Use Only.
RUSKI-201 is a potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM.
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RUSKI-201 is a potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM.
RUSKI-201 blocks Hh signaling in H520, Panc-1, and MCF-7 coculture with Shh-Light2 cells (IC50=4.8 uM, 7.8 uM, and 8.5 uM, respectively).
RUSKI-201 selectively inhibits Hh palmitoylation over a panel of >100 palmitoylated substrates in cells.
| M.Wt | 357.516 | |
| Formula | C20H27N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rodgers UR, et al. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262.
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