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Chemical Structure : SF-1126
Catalog No.: PC-60413Not For Human Use, Lab Use Only.
SF-1126 is a pan PI3K/BRD4 inhibitor, RGDS-conjugated LY294002 prodrug that exhibits increased solubility and binds to specific integrins.
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SF-1126 is a pan PI3K/BRD4 inhibitor, RGDS-conjugated LY294002 prodrug that exhibits increased solubility and binds to specific integrins; blocks expression levels of c-Myc in HCC cells, inhibits proliferation, cell cycle, apoptosis, PI3K/AKT/mTOR and Ras/Raf/MAPK pathway; shows significant antitumor activity in vivo.
Liver Cancer
Phase 1 Clinical
| M.Wt | 852.84 | |
| Formula | C39H48N8O14 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Garlich JR, et al. Cancer Res. 2008 Jan 1;68(1):206-15.
2. Dittmann A, et al. ACS Chem Biol. 2014 Feb 21;9(2):495-502.
3. Erdreich-Epstein A, et al. Oncotarget. 2016 Nov 16. doi: 10.18632/oncotarget.13386.
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