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Chemical Structure : ST-115
Catalog No.: PC-72623Not For Human Use, Lab Use Only.
ST-115 (ST115) is a potent and specific inhibitor of aminopeptidase P2 ((XPNPEP2, APP2) with IC50 of 3.7 nM.
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ST-115 (ST115) is a potent and specific inhibitor of aminopeptidase P2 (XPNPEP2, APP2) with IC50 of 3.7 nM.
ST-115 does not inhibit ACE, neprilysin, or multiple other enzymes, and littile inhibition against Aminopeptidase P1/A/B/N (IC50=600 nM->10 uM).
ST-115 can reduce bradykinin degradation, increasing its concentration and protective effects when administered intravenously at the start of reperfusion, reduced damaged area of the heart in a mouse model of myocardial infarction.
In a rat model of ischemic stroke, ST-115 reduced functional deficits in a skilled walking test by 60% and reduced brain edema by 51%.
ST-115 also reduced brain infarct size by 48% in a major subset of rats with small strokes.
| M.Wt | 457.561 | |
| Formula | C21H32FN3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Morgan Rae Lenz, et al. J Pharmacol Exp Ther. 2022 Jan 3;JPET-AR-2021-000875.
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